Discuss How Glycogen is synthesised Angelina Lorenos

DISCUSS HOW GLYCOGEN IS SYNTHESISED GENERAL STRUCTURE INFORMATION glycogen costs polymers of glucose, tie in by á 1-4 glycosidic bonds. The tree branch points are linked by á 1-6 glycosidic bonds. The branch points legislate at 8, 9 or 10 residue spacings along the linear chain. FORMATION OF UDP GLUCOSE Glucose is transported into cells by a glucose transporter - a membrane bound protein. It is phosphorylated to rake glucose-6- orthophosphate. This is catalysed by hexokinase. ATP is converted to ADP, which provides the Pi required for the phosphorylation. isomerization of glucose-6-phospate imprints glucose-1-phosphate. This is catalysed by phosphoglucomtase. The enzyme Uridine diphosphate (UDP) glucose pyrophosphorylase then catalyses the synthesis of UDP glucose from glucose-1-phosphate. UDP glucose is the metabolically active contrariety of glucose, i.e. the form of glucose which is appropriate for animal starch synthesis. This conversion moldiness occu r before glycogen can be synthesised. Glucose Hexokinase Glucose-6-phosphate Phosphoglucomutase Glucose-1-phosphate UDP glucose pyrophosphorylase UTP PPi UDP Glucose water system 2 Pi MAINTENANCE OF FORMATION OF GLYCOGEN Pyrophosphate (PPi) form in this reaction step is hydrolysed to form two phosphate (Pi) species. This enzymatic cleavage is mediated by pyrophosphatase. This step is passing exergonic - about 30kJmol-1 under standard conditions.

This step is relevant to glycogen synthesis since it draws the reaction (UDP-glucose physical composition from glucose-1-phosphate) to the right, maintainin g the formation of UDP-glucose and hence th! e formation of the glycogen polymer. FORMATION OF GLYCOGEN FROM UDP GLUCOSE UDP-glucose donates its glucosyl moiety (the trigger off sugar unit) to the non-reducing leftover of a glycogen branch. The glycogen branch must comprise at least 4 residues of glucose. This rise to power reaction generates an á 1-4 glycosidic linkage - so called because the link forms between the atomic number 6 1 of the first appearance glucosyl moiety and carbon 4 of the glucose residue at the consequence of the chain. Glycogen synthase... If you want to ask a full essay, rear it on our website: OrderCustomPaper.com

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